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Table 1 Pearson’s correlation analysis of locus position and gene expression

From: Gene repositioning within the cell nucleus is not random and is determined by its genomic neighborhood

Condition Lower CI Upper CI R p value
(A) Gene of interest
 Differentiation Locus–periphery −1 0.2587 −0.3425 0.1663
Locus–chromocenter −0.4619 1 0.121 0.3692
 Ectopic Locus–periphery −1 0.1083 −0.556 0.07627
Locus–chromocenter −0.0698 1 0.582 0.06501
(B) BAC (≈180 kbp)
 Differentiation Locus–periphery −1 0.4907 −0.085 0.4082
Locus–chromocenter −0.2949 1 0.307 0.1937
 Ectopic Locus–periphery −1 0.3716 −0.227 0.2638
Locus–chromocenter −0.2237 1 0.375 0.1429
(C) 2-Mbp region
 Differentiation Locus–periphery −1 −0.0516 −0.587 0.0372
Locus–chromocenter −0.2413 1 0.359 0.1543
 Ectopic Locus–periphery −1 −0.1764 −0.723 0.0214
Locus–chromocenter 0.1386 1 0.704 0.0257
(D) 5-Mbp region
 Differentiation Locus–periphery −1 0.2243 −0.374 0.1433
Locus–chromocenter −1 0.5311 −0.030 0.4672
 Ectopic Locus–periphery −1 0.317 −0.386 0.1724
Locus–chromocenter −0.0235 1 0.459 0.1261
  1. Differentiation and ectopic MeCP2 systems were analyzed relating normalized locus positions and maximum gene expression values (see Fig. 2). Different region sizes were analyzed: (A) single gene level; (B) BAC level, corresponding to an average of 180 kbp; (C) genomic 2-Mbp window; (D) genomic 5-Mbp window. Pearson’s coefficients (R) are given together with upper and lower confidence intervals (CI) and p values for each condition as indicated