|
Condition
|
Lower CI
|
Upper CI
|
R
|
p value
|
|---|
|
(A) Gene of interest
|
|
Differentiation
|
Locus–periphery
|
−1
|
0.2587
|
−0.3425
|
0.1663
|
|
Locus–chromocenter
|
−0.4619
|
1
|
0.121
|
0.3692
|
|
Ectopic
|
Locus–periphery
|
−1
|
0.1083
|
−0.556
|
0.07627
|
|
Locus–chromocenter
|
−0.0698
|
1
|
0.582
|
0.06501
|
|
(B) BAC (≈180 kbp)
|
|
Differentiation
|
Locus–periphery
|
−1
|
0.4907
|
−0.085
|
0.4082
|
|
Locus–chromocenter
|
−0.2949
|
1
|
0.307
|
0.1937
|
|
Ectopic
|
Locus–periphery
|
−1
|
0.3716
|
−0.227
|
0.2638
|
|
Locus–chromocenter
|
−0.2237
|
1
|
0.375
|
0.1429
|
|
(C) 2-Mbp region
|
|
Differentiation
|
Locus–periphery
|
−1
|
−0.0516
|
−0.587
|
0.0372
|
|
Locus–chromocenter
|
−0.2413
|
1
|
0.359
|
0.1543
|
|
Ectopic
|
Locus–periphery
|
−1
|
−0.1764
|
−0.723
|
0.0214
|
|
Locus–chromocenter
|
0.1386
|
1
|
0.704
|
0.0257
|
|
(D) 5-Mbp region
|
|
Differentiation
|
Locus–periphery
|
−1
|
0.2243
|
−0.374
|
0.1433
|
|
Locus–chromocenter
|
−1
|
0.5311
|
−0.030
|
0.4672
|
|
Ectopic
|
Locus–periphery
|
−1
|
0.317
|
−0.386
|
0.1724
|
|
Locus–chromocenter
|
−0.0235
|
1
|
0.459
|
0.1261
|
- Differentiation and ectopic MeCP2 systems were analyzed relating normalized locus positions and maximum gene expression values (see Fig. 2). Different region sizes were analyzed: (A) single gene level; (B) BAC level, corresponding to an average of 180 kbp; (C) genomic 2-Mbp window; (D) genomic 5-Mbp window. Pearson’s coefficients (R) are given together with upper and lower confidence intervals (CI) and p values for each condition as indicated
