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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response

Fig. 3

Comparison of gene populations whose transcript levels change at different concentrations of VPA and SAHA. Venn diagrams show overlap of genes responding significantly (ANOVA, fold change >1.5, FDR <10 %) to one of three concentrations of either VPA or SAHA. a Comparison of genes responding significantly to three different concentrations of SAHA or VPA, as indicated. b Comparison of significant genes responding to VPA and SAHA at each concentration (low = 0.2 mM VPA, 0.5 µM SAHA; medium = 1 mM VPA, 2.5 µM SAHA; high = 5 mM VPA, 12.5 µM SAHA).

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