Fig. 4From: The BisPCR2 method for targeted bisulfite sequencingValidation of CpG loci differentially methylated in type 2 diabetic pancreatic islets by BisPCR2. Average percent CpG methylation in 5 non-diabetic and 5 type 2 diabetic human islet samples at loci previously shown to be differentially methylated in type 2 diabetic human islets, including a INS, b IRS1, c CDKN1A, and d PDE7B. Black arrows indicate CpGs analyzed previously by pyrosequencing by Dayeh and colleagues [18]. p value calculated by two-tailed t tests. *p < 0.05. Error bars indicate SEM.Back to article page