Intra-species chromatin divergence of every gene. Genes were segmented in bins corresponding to percentiles of the gene body (from TSS to TES) plus 500 bp of the upstream and downstream regions. For every gene, the divergence was quantified from an ANOVA model and termed ‘epidiv’ (see “Methods”). a Examples of genes with low (0.35) and high (>100) epidiv values. The normalized ChIP/MNase profiles are colored according to strains. Black BY, red RM and green YJM. b Epidiv values as a function of DNA sequence divergence of every gene. c Epidiv values as a function of transcription responsiveness from . The red line is a smoothed average, showing that the correlation is mainly supported by highly responsive genes. ρ Spearman correlation coefficient. P value: significance rank-based correlation test. d Epidiv values for genes with or without a TATA box . P value: Wilcoxon Mann–Whitney test. Colored bar median.