Fig. 5
From: Modelling the conditional regulatory activity of methylated and bivalent promoters
Illustration of our predictive modelling approach where the H2A.Z histone variant has been used to separate genes into two classes. Categorising genes by the presence of promoter-localised H2A.Z removes context sensitivity in the regulatory role of H3K4me3; H3K4me3 in the presence of H2A.Z is often a hallmark of low expression (i.e. bivalent genes), whereas H3K4me3 is otherwise associated with active transcription. These conditional interactions are poorly handled by previous regression models