Fig. 1
From: Modelling the conditional regulatory activity of methylated and bivalent promoters
Illustration of the histone/epigenetic code in the context of the promoter-localised regulatory elements analysed in this study. Only active genes exhibit significant expression, corresponding with H3K4me3 often flanked by H2A.Z. Poised and reversible/permanently silenced genes are distinguished by decreasing likelihood of genes returning to an active state; poised genes are marked by bivalent H3K4/27me3 and H2A.Z, while silent genes are marked by H3K27me3 (facultative heterochromatin), H3K9me3 (constitutive heterochromatin) and DNA methylation (permanent silencing)