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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Divergence of transcriptional landscape occurs early in B cell activation

Fig. 6

Response selective expression of miRNAs. a Differential expression of 60 miRNAs is shown with heatmap values indicating no change (black), increase (red), or decrease (blue) compared to the resting state. An increase or decrease was minimally a twofold difference. b miRNAs increased (red) or decreased (blue) in both BCR and LPS activation with numbers of miRNAs in parentheses, two examples from each group, and published biological effects from miRNAs in each group. c miRNAs preferentially increased (red) or decreased (blue) in either BCR or LPS activation with numbers of miRNAs in parentheses, two examples from each group, and published biological effects from miRNAs in each group. Venn diagrams show miRNAs common to opposing reactions to activation states; increased in BCR/decreased in LPS or decreased in BCR/increased in LPS. (Asterisk) miRNAs common to opposing responses with four representatives for those decreased in BCR and increased in LPS shown. d UCSC Genome Browser track visualization of two miRNA clusters; resting (grey), BCR (blue), and LPS (yellow)

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