Fig. 3
From: Divergence of transcriptional landscape occurs early in B cell activation
Differential response of histone marks. a H3K4me3 normalized mean RPM were mapped 2 kbp relative to average TSS of genes with increased transcription shared between the two activation states (far left), exclusive to BCR (middle left), exclusive to LPS (middle right), and in genes with substantial but unchanged transcription relative to the resting state (far right). Reads from the resting state are in grey, BCR in blue, and LPS in orange. b Boxplots contain the sums of mapped H3K4me3 normalized mean RPM +/−1 kbp relative to average TSS; resting (grey), BCR (blue), LPS (orange), and number of genes indicated in parentheses. Non-significant (NS) (P > = 0.05) or significant (*, P < 0.05) from Wilcoxon Rank Sum Testing. Asterisk or NS on top indicates a difference from the resting state and at the bottom between the BCR and LPS states. c H3K27me3-normaliized mean reads per million 4 kb on either side of average TSS of genes. d Boxplots contain the sums of mapped H3K27me3 normalized mean RPM +/−1 kb relative to average TSS; resting (grey), BCR (blue), LPS (orange), and number of genes indicated in parentheses. Non-significant (NS) (P > = 0.05) or significant (*, P < 0.05) from Wilcoxon Rank Sum Testing. Asterisk or NS on top indicates a difference from the resting state and at bottom between the BCR and LPS states