Fig. 1

Differential transcription regulation signatures by two B cell activation modes. Clustered heatmaps of RNA-seq data show genes with increased (red) or decreased (blue) transcription shared by both stimulated cell types (a) or preferred during either response; for example, BCR > LPS, see Methods for further explanation (b). c Gene lists associated within each cluster are represented by heatmaps shown in (a) and (b) and their relationship to processes were analyzed for significant, P < 0.05, relationships. For each gene (red) in a differential expression cluster, e.g. BCR > LPS, an association with a particular processes or regulatory element is indicated with a line. Myc and NF-κB, along with the genes, processes and regulatory elements directly associated with them are shown in yellow