Figure 7
HP1a has a role in setting H3K27me3 levels. H3K27me3 ChIP data from wild-type, single or trans-heterozygous mutant third instar larvae. Mutation from the mother listed first (*/+), mutation from father listed second (+/*). The same applies for the double heterozygous condition. Strong loss of function or null alleles were used: Su(var)2-5 05, Su(z)124, and Pc 15. (A) Promoters of silenced genes (hb, nullo, bnk) and active genes (Ubx, h); (B) heterochromatic regions (1360, HeT-A, TART and F-element). Broken line across is wild-type signal level. Asterisks show genotypes significantly different from wild-type and between the parental switch for Su(var)2-5 and Pc; number symbol (#) shows significant differences between same genotype but the mutation is inherited from the opposite parent. *P value <0.05, **P value <0.005, ***P value <0.0005 (same applies for #). Error bars represent ± SEM. ns, not significant; hb, hunchback; bnk, bottleneck; Ubx, Ultrabithorax; h, hairy; NI, non-immune; Su(z)12, suppressor of zeste 12.