Figure 3From: A balancing act: heterochromatin protein 1a and the Polycomb group coordinate their levels to silence chromatin in Drosophila Reduction in HP1a consistently reduces H3K27me3 levels at gene promoters. (A) Levels of H3K27me3 in 1–3 h embryos at different gene regions in addition to their promoters. Heterochromatin is represented in (B) by the 1360 repetitive element, TART and HeT-A telomeric elements, and the F-element found in pericentric heterochromatin as well as other heterochromatic regions across the genome. Most of the genes (five of the nine) show a decrease also at their 3′ ends and for Sxl and Ubx, 1 kb downstream of the promoter (labeled mid). Three of the nine (hb, nullo, and lt) show an increase while bnk did not show a change. Two of the repetitive regions are unchanged (TART, F-element) while the remaining two show a decrease (1360, HeT-A). Asterisks show changes which are significant different from wild-type (*P value <0.05, **P value <0.005, ***P value <0.0005). Error bars represent ± SEM. NI, non-immune; Sxl, Sex-lethal; Ubx, Ultrabithorax; hb, hunchback; tsr, twinstar; bnk, bottleneck; h, hairy; lt, light; cta, concertina.Back to article page