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Figure 3 | Epigenetics & Chromatin

Figure 3

From: A balancing act: heterochromatin protein 1a and the Polycomb group coordinate their levels to silence chromatin in Drosophila

Figure 3

Reduction in HP1a consistently reduces H3K27me3 levels at gene promoters. (A) Levels of H3K27me3 in 1–3 h embryos at different gene regions in addition to their promoters. Heterochromatin is represented in (B) by the 1360 repetitive element, TART and HeT-A telomeric elements, and the F-element found in pericentric heterochromatin as well as other heterochromatic regions across the genome. Most of the genes (five of the nine) show a decrease also at their 3′ ends and for Sxl and Ubx, 1 kb downstream of the promoter (labeled mid). Three of the nine (hb, nullo, and lt) show an increase while bnk did not show a change. Two of the repetitive regions are unchanged (TART, F-element) while the remaining two show a decrease (1360, HeT-A). Asterisks show changes which are significant different from wild-type (*P value <0.05, **P value <0.005, ***P value <0.0005). Error bars represent ± SEM. NI, non-immune; Sxl, Sex-lethal; Ubx, Ultrabithorax; hb, hunchback; tsr, twinstar; bnk, bottleneck; h, hairy; lt, light; cta, concertina.

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