Figure 5

Association of TF binding with strength of enhancement in high-throughput enhancer assays. Distribution of expression levels of (A) 320 DNA segments with GATA motif instances that are in enhancer chromatin states in K562 cells [27], and (B) 1,499 DNA segments that are in enhancer chromatin states in K562 cells [28]. The assayed DNA segments were categorized as TF bound or TF unbound based on overlap with ChIP-seq peaks for EP300, TAL1, GATA1, or GATA2 in K562 cells [51]. The distribution of enhancer activities (from [27] and [28]) in each category is presented as box plots. The total numbers of DNA segments in each category are given at the bottom of the plots. The horizontal internal line and the diamond shape indicate the median and mean of enhancer activity in each category, respectively.