Meta-analysis of contributions of epigenetic features to enhancer activity. The sensitivity and specificity of epigenetic features singly and in combination for prediction of enhancer activity were evaluated for 273 DNA segments tested in transient transfection assays. The results are displayed as a receiver-operator characteristic (ROC) graph. The graphs in (A) show the results for informative groups of features, and (B) shows the results for all combinations of features. Abbreviations and color code are defined in panel (B). The top eight discriminators with the best performance (dots in the upper left) are labeled in (B). (C) Dot plot illustrating the distance of 74 feature and feature combinations to the point with the best discriminator performance (Sn = 1 and Sp = 1).