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Figure 4 | Epigenetics & Chromatin

Figure 4

From: Proteogenomics analysis reveals specific genomic orientations of distal regulatory regions composed by non-canonical histone variants

Figure 4

Histone variants are associated with PolII orientation. (A) The profiles of H3.3 and H2A.Z are associated with the pattern of PolII and enhancer transcripts. For symmetric clusters, PolII is located at the center. For asymmetric clusters, PolII is skewed to the direction of the peaks of histone variants. Transcripts at enhancers show bidirectional patterns. Strand-specific transcripts are stronger in the asymmetric clusters. (B) The screenshot of histone variant around DNaseI. H3.3 is enriched more to the right side of the peak of DNaseI. PolII has its peak to the right side of DNaseI. (C) ChIP-qPCR validation on the seven regions. PolII enrichment is skewed towards the right side.

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Epigenetics & Chromatin

ISSN: 1756-8935