Skip to main content
Figure 3 | Epigenetics & Chromatin

Figure 3

From: Proteogenomics analysis reveals specific genomic orientations of distal regulatory regions composed by non-canonical histone variants

Figure 3

Genomic profiles of histone variants. (A) Distribution of ChIP-seq reads at annotated TSSs (±2 K) and TTSs (±500) and (B) at distal regulatory regions. We clustered DHSs located in the intergenic region. We identified 16 groups and rearranged them to 10 clusters based on their profiles. Various compositions of histone variants were found. Clusters 5 to 10 are composed of 2 mirroring groups. After clustering based on histone variants, we aligned histone modification. Histone variants are off-centered for the mirroring clusters (clusters 5 to 10), suggesting orientation at regulatory regions. (C) Symmetric and asymmetric profiles of histone variants. Clusters 1 and 4 show symmetric profiles with various compositions of histone variants. Cluster 5 shows mirroring asymmetric profile. All profiles for all clusters are shown in Additional file 3: Figure S2.

Back to article page