Figure 7

Effects of drug treatments on WNT pathway genes. (A) Shown are the expression changes in previously identified WNT pathway genes (http://www.stanford.edu/group/nusselab/cgi-bin/wnt/) that have a detection P value <0.01 and a differential P value <0.05 after 96 h of treatment of HCT116 or PANC1 cells with either ICG-001 (ICG) or C646; see Additional file 7. (B) Shown are the predicted results (based on the model shown in Figure 1) and the actual responses to the drugs after treatment of HCT116 or PANC1 cells for a set of WNT target genes. In the prediction column, a red arrow indicates that the gene should have been upregulated by ICG-001 and the green arrow indicates that the gene should have been downregulated by ICG-001, according to the model. For each cell type, the actual response is shown for both drugs: a red arrow indicates that expression was increased as predicted by the model, a green arrow indicates expression was decreased as predicted by the model, a gray arrow indicates that the expression pattern upon treatment did not correspond to the prediction, and an x indicates that the gene was not expressed in that cell line.