Figure 2
From: Altering cancer transcriptomes using epigenomic inhibitors
The effects of epigenetic inhibitors on the transcriptome of HCT116 and PANC1 cells. HCT116 colon cancer cells and PANC1 pancreatic adenocarcinoma cells were treated in duplicate with DMSO or 10 uM ICG-001 or C646 for 12 or 96Â h (12 samples per cell line). Cells were harvested and RNA was analyzed using Illumina HumanHT-12 v4 expression arrays. Any gene having a detection P value <0.01 in any of the samples was selected for differential gene analysis; genes having a differential P value <0.05 were further analyzed. The number of upregulated (red) and downregulated (green) genes under each condition for each cell line is shown.