A refined model for an epigenetic switch that initiates and maintains transformation. (A) Model of the epigenetic switch and its positive feedback loops that mediate transformation. Dashed lines indicate predicted interactions based on literature findings. Red lines indicate direct transcriptional regulation. Black lines ending in an arrow or perpendicular slash indicate known positive and inhibitory interactions, respectively, within MCF10-ER-Src based on previous experimental findings and this work. A thin line indicates weak activity. A green star represents interactions based on data presented in this work. (B) The major phenotypic effects and processes mediated by STAT3, NF-κB, and FOS.