DMR caller candidate performance and accompanying ground truth DMR size.
(a) AUCPR for four 450K-DMR-calling methods (log scale), validated on a series of DMRs called from WGBS from the same DNA samples, called by varying the BSmooth |t| cutoff parameter, for the VA vs SA comparison. (b) AUCPR (log scale) on the candidate methods for the VA vs VAT comparison. (c)
BSmooth-called DMR widths (log scale) from the WGBS data, for the VA vs SA comparison. Yellow dots indicate the median length in this and the following panel. (d)
BSmooth-called DMR widths (log scale) from the WGBS data, for the VA vs VAT comparison. AUCPR, area under the precision–recall curve; DMR, differentially methylated region; SA, subcutaneous adipocyte; VA, visceral adipocyte; VAT, visceral adipose tissue; WGBS, whole-genome bisulfite sequencing.