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Table 7 CENP-A is enriched at the 8q24/ Myc locus in tumor-derived SW480 cells and in human tumors

From: CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells

 

Cell line/tumor

Probe

Cells with co-localization a (%)

Cells counted (N)

Cell Line

HeLa

Myc

5

20

Cell Line

SW480

Myc

66

32

Cell Line

Normal Colon

8q24

1

100

Cell Line

HeLa

8q24

8

100

Cell Line

SW480

8q24

38

100

Tissue

Normal

8q24

0

30

Tissue

Tumor 1

8q24

32.9

82

Tissue

Tumor2

8q24

36.5

85

Tissue

Tumor 3

8q24

42.9

49

Tissue

Tumor 4

8q24

78.4

88

  1. aQuantification of CENP-A and 8q24/Myc co-localization in cancer cells and tumors after co-immunofluorescence demonstrates that a statistically significant enrichment of CENP-A occurs on one of the translocated 8q24/Myc loci. White spots denoting co-localization were detected using Image J’s automated co-localization algorithm.