| Analysis of more than two PTM states | Analysis of direct intranucleosomal connection | Ability to enrich combinatorial PTMs | Ability to quantify combinatorial PTMs | Ability to map combinatorial PTMs to the genome | Antibody -free |
---|---|---|---|---|---|---|
MARCC-quantitative mass spectrometry (this report) | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ |
✔ |  |  |  | ✔ |  | |
 | ✔ | ✔ |  | ✔ |  | |
✔ | ✔ |  | ✔ |  |  | |
Middle-down histone mass spectrometry [4] | ✔ | ✔ (within one histone tail) |  | ✔ |  | ✔ |