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Table 1 Comparison between different methodologies for analyzing chromatin states with combinatorial histone PTMs

From: ChIP-less analysis of chromatin states

  Analysis of more than two PTM states Analysis of direct intranucleosomal connection Ability to enrich combinatorial PTMs Ability to quantify combinatorial PTMs Ability to map combinatorial PTMs to the genome Antibody -free
MARCC-quantitative mass spectrometry (this report)
Overlaying ChIP-sequencing tracks [1418]     
ChIP-re-ChIP [19, 20]    
ChIP-quantitative mass spectrometry [2, 21, 22]    
Middle-down histone mass spectrometry [4] ✔ (within one histone tail)