Figure 4

C/EBPβ and CTCF chromatin immunoprecipitation (ChIP)-seq peaks in fibroblasts and keratinocytes. (a) Venn diagram showing C/EBPβ ChIP-seq peaks in fibroblasts and keratinocytes. The common peaks are in methylated regions (61%) and tissue-specific C/EBPβ peaks are even more enriched in methylated regions (approximately 70%). (b) Scatter plot of number of reads in C/EBPβ bound ChIP peaks in dermal fibroblasts and keratinocytes. (c) Venn diagram showing that the majority of CTCF ChIP-seq peaks overlap between fibroblast and keratinocyte. 96% of the common peaks are in unmethylated regions and enriched in the promoters (87%). The tissue-specific CTCF peaks are also primarily in unmethylated regions enriched for promoters. The 3% of common CTCF peaks in methylated regions tend to occur in exons (64%). (d) Scatter plot of number of reads in CTCF bound ChIP peaks in dermal fibroblasts and keratinocytes.