Nucleosome organization at extended HMRs in fibroblasts. (a) Heatmap of CG methylation in fibroblasts (Fb) and keratinocytes (Ker) for the common HMRs in which one boundary is identical, but the other boundary is extended in fibroblasts. The boundaries of these HMRs are grouped into three types: identical in two cells (boundary 1), not identical with short end (boundary 2), and with long end (boundary 3). These HMRs are aligned by boundary 2. (b) Heatmap of nucleosome positioning in fibroblasts and keratinocytes for the overlapping HMRs extended in fibroblasts aligned by boundary 2. (c) Average nucleosome density in fibroblasts (blue), keratinocytes (red), and intrinsic nucleosome occupancy scores (INOS, black) for each boundary type of the extended HMRs.