Nucleosome organization in non-CGI HMRs is not dependent on methylation status. (a, b) Heatmap of nucleosome density in fibroblasts (Fb.) surrounding non-CGI containing HMRs for (a) common (found at both keratinocytes and fibroblasts), and (b) fibroblast-specific HMRs. (c, d) Heatmap of nucleosome density surrounding non-CGI containing HMRs in keratinocyte (Ker.) for (c) common and (d) keratinocyte-specific HMRs. For all heatmaps, HMRs in each class are sorted by length. (e-g) Average nucleosome occupancy measured in fibroblasts (blue), and keratinocytes (red), and intrinsic nucleosome occupancy scores (INOS, black) surrounding the 5′ unmethylated CG of the HMR boundary for (e) common non-CGI HMRs, (f) fibroblast specific non-CGI HMRs, and (g) keratinocyte-specific non-CGI HMRs.