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Figure 3 | Epigenetics & Chromatin

Figure 3

From: Chd1 co-localizes with early transcription elongation factors independently of H3K36 methylation and releases stalled RNA polymerase II at introns

Figure 3

Loss of Chd1 leads to changes in local occupancy of RNAPII Ser 5-P. (A) Wide view shows no large-scale occupancy changes of either form of elongating RNAPII between wild-type (WT) and chd1Δ. (B) Close-up of highly transcribed genes showing that RNAPII Ser 5-P shifts upstream in chd1Δ, but RNAPII Ser 2-P peaks appear very similar between WT and chd1Δ. (C) shapeDiff quantification of the peak shape similarity of RNAPII Ser 5-P and RNAPII Ser 2-P between WT and chd1Δ. The effect of CHD1 deletion on changes in peak shape is much stronger for RNAPII Ser 5-P than for RNAPII Ser-2 P.

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Epigenetics & Chromatin

ISSN: 1756-8935