Figure 7
From: The C. elegans dosage compensation complex mediates interphase X chromosome compaction
X chromosome compaction is dependent on the DCC and the DCC-mediated histone modifications. A graphical cartoon illustrates DCC and DCC-mediated histone modifications effects on hermaphrodite X chromosome structure. The DCC binds to both hermaphrodite X chromosomes and by regulating SET-1 and SET-4, mediates an enrichment of H4K20me on the X chromosome, which, in turn, through SIR-2.1 activity, depletes H4K16ac. These activities compact the X chromosome territories and downregulate X-linked gene expression by half.