Figure 6

Depletion of the DCC-meditated histone modifiers leads to the loss of X chromosome compaction. (A) Quantification of the percentage of nuclear volume occupied by X in wild type (n = 40), set-1(tm1821) (n = 40), set-4(n4600) (n = 40) and sir-2.1(ok434) (n = 40). Error bars indicate standard deviation. Asterisks indicate level of statistical significance by t-test analysis (three asterisks, P <0.001). (B) Quantification of the percentage of nuclear volume occupied by chromosome I in wild type (n = 40), set-1(tm1821) (n = 20), set-4(n4600) (n = 40), and sir-2.1(ok434) (n = 40). Error bars indicate standard deviation.