Figure 6
From: A global assessment of cancer genomic alterations in epigenetic mechanisms
Mutational and transcriptional alterations associated with activating and repressive epigenetic marks. (A, B) The epigenetic dashboard reflects the effect of epigenetic states on transcriptional activation status [62]. Most alterations recurrently observed in cancer patients are shifting the epigenetic machinery towards a transcriptionally repressed state (to focus on transcriptional variations of high-amplitude and simplify the list, Log2(mRNA tumor/matched control) cutoffs of 1 and -1 were used for over- and underexpression, respectively). (C) Heatmaps are shown for enzymes writing or erasing activating (H3K4me3, H3K36me3) or repressive (H3K9me3, H3K27me3) histone marks, and for enzymes methylating or demethylating DNA as well as UHRF1.