Ravines are associated with higher transcriptional activity. (A) Resorts are classified based on steepness, with the steepest 1500 resorts forming the steep ravine class and the least steep unmethylated resorts forming the uniformly unmethylated class. (B) Distribution of DNase sensitivity scores for each resort class. (C) Distribution of gene expression levels of all genes associated (5’, promoter or intragenic) with a CGI in the uniformly unmethylated, ravine or other resort classes. Density of DNase scores and expression levels are shown by the violin plots behind the box plots.