CGCGC motif analyses. (A) Motifs reported by DREME as the most significantly enriched in the set of intragenic unmethylated CpG islands (CGIs) (n = 259) compared to the set of intragenic methylated CGIs (n = 545). The CGCGC motif is the most significant motif with an extremely small E-value relative to the other reported motifs. (B) E-value distribution resulting from the de novo motif search comparing unmethylated intragenic with methylated intragenic CGIs that identified the CGCGC motif. The CGCGC motif is the short bar in the bottom-left corner, reported as nine orders of magnitude more significant than any of the other identified motifs. Similarly, TGCCGC was six to eight orders of magnitude more significant than any of the other reported motifs (Figure 2.B). (C) Presence statistic for the CGCGC motif per CGI category. (D) Density of the CGCGC motif per CGI category. DMRs, maternal permanent gDMR CGIs.