DNA methylation dynamics during ex vivo differentiation and maturation of human dendritic cells

Table 1 Numbers of differentially methylated CG sites (DMPs) identified during ex vivo dendritic differentiation and maturation

Comparisons (G1 versus G2)	Numbers of DMPs^a		Locations of DMPs relative to CpG islands (%)				Enhancer associated^e	Promoter associated^f	Gene associated^g
Comparisons (G1 versus G2)	G1 > G2	G1 < G2	Islands	Shores^b	Shelf^c	>4 kb^d	Enhancer associated^e	Promoter associated^f	Gene associated^g
CD14⁺ versus immature dendritic cell (iDC)	1368	240	5.9	23.5	16.1	54.5	701	139	933
iDC versus mature dendritic cell (mDC)	139	17	3.3	18.2	14.9	63.6	80	9	116

^aP value cutoff of 0.05, difference change of 10% in DNA methylation was used to calculate the number of DMPs (see Methods).
^bShores were defined for this table as 2 kb from an island (N and S island).
^cShelves were defined for this table as 2 kb-4 kb away from an island (N and S shore).
^dRegions over 4 kb from an island.
^{e, f, g}Based on HumanMethylation450 v1.2 Manifest File (http://support.illumina.com/downloads/infinium_humanmethylation450_product_files.html).

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