Telomere shortening and telomere position effect in mild ring 17 syndrome

Table 1 Expression levels of selected sub-telomere genes of the ring17 patient, significantly deregulated compared with controls

Gene symbol	Gene name	Fold change	P
		(standard deviation)
17p: 1 to 1,500,000
RPH3AL	Rabphilin 3A-like (without C2 domains)	−2.99 (0.15)	0.001
FAM57A	Family with sequence similarity 57, member A	−1.61 (0.04)	0.002
GEMIN4	Gem (nuclear organelle) associated protein 4	−1.70 (0.03)	0.001
RNMTL1	RNA methyltransferase like 1	1.13 (0.03)	0.018
NXN	Nucleoredoxin	−1.87 (0.05)	0.001
YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	−1.04 (0.01)	<0.001
MYO1C	Myosin IC	−1.15 (0.01)	0.001
17q: 79,695,210 to- 81,195,210
ARHGDIA	ρ GDP dissociation inhibitor α	−1.67 (0.02)	<0.001
SIRT7	Sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)	−1.09 (0.01)	0.010
NARF	Nuclear prelamin A recognition factor	−1.86 (0.02)	<0.001
FOXK2	Forkhead box K2	−1.44 (0.07)	0.008
FN3K	Fructosamine 3 kinase	−2.18 (0.06)	<0.001

Genes are listed from the telomere down to 1.5 Mb on the p arm and from the position 79,695,210 of the q arm up to the telomere. The expression values are reported as the mean fold change of three replicates.

ISSN: 1756-8935