Figure 2
From: Telomere shortening and telomere position effect in mild ring 17 syndrome
Quantitative fluorescence in-situ hybridization (Q-FISH) results. (A, B) Chromosome-specific telomere lengths, as evaluated in (A) normal and (B) ring metaphases in lymphocytes established from the proband (III-1). Chromosome 17 telomere lengths in ring metaphases refer solely to the homolog of the ring chromosome. (C) Average telomere length in ring chromosome, in the homolog of the ring chromosome and in normal chromosomes 17 from normal metaphases (p-ter + q-ter), as addressed by Q-FISH analysis in lymphocytes established from proband (III-1) and her mother (II-2). (D, E) Comparison between chromosome 17 telomere length (p-ter + q-ter) in r17 family members and age-matched controls. Control values were represented as (D) independent or (E) averaged values. (F, G) Comparison between the mean cellular telomere length in r17 family members and age-matched controls. Control values were represented as (F) independent or (G) averaged values.