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Table 4 Multiple linear regression models in which technical versus biological components of transcriptional noise are separately analyzed

From: DNA methylation and transcriptional noise

Predictors

Estimate of β

t value

Significance

VIF

Model 1a

    

Intercept

1.201

14.12

<10-4

 

Expression

−0.442

−78.19

<10-4

1.06

Gene body methylation

−0.797

−7.33

<10-4

1.07

Promoter methylation

0.613

6.17

<10-4

1.06

Adjusted R2

   

0.53

Model 2b

    

Intercept

0.769

11.157

<10-4

 

Expression

−0.337

−61.354

<10-4

3.39

Gene body methylation

−0.566

−9.463

<10-4

1.10

Promoter methylation

0.431

7.969

<10-4

1.07

Technical noise

0.608

32.467

<10-4

3.30

Adjusted R2

   

0.82

  1. aModel 1 used CV calculated from biological component as response variable.
  2. bModel 2 used CV calculated from total variation as response variable.
  3. CV, coefficient of variation; VIF, variance inflation factor.