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Figure 5 | Epigenetics & Chromatin

Figure 5

From: Murine esBAF chromatin remodeling complex subunits BAF250a and Brg1 are necessary to maintain and reprogram pluripotency-specific replication timing of select replication domains

Figure 5

Replication timing changes are not associated with transcriptional changes. (A) Replication timing changes of Brg1-affected domains in ESC (4-hydroxytamoxifen (OHT) ratio - mock ratio) were plotted against transcriptional changes after Brg1 knockdown in embryonic stem cell (ESC) (Brg1 knockdown (Brg1 KD) ratio - control green fluorescent protein knockdown (GFP KD)) [35]. (B) Box plots show the transcriptional changes in Brg1-affected EtoL and LtoE domains (false discovery rate (FDR) = 1% and 5% segments from Figure 3D) compared to non-switching late (LtoL) or early (EtoE) domains.

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Epigenetics & Chromatin

ISSN: 1756-8935