Figure 3
From: Haploid genomes illustrate epigenetic constraints and gene dosage effects in mammals
Haploid phases are observed in human tumors. Haploid phases in human tumors could facilitate or accelerate the loss of tumor suppressor gene function. Mutations that have been introduced into the haploid tumor genome will become homozygous when the tumor cell becomes diploid or polyploid. The observation of tumors with cells at various polyploidy levels can follow a transient haploid phase, which makes recognition of haploid phases difficult.