Table 2 Expression levels of epidermis genes and DNA methylation factors
From: Aging is associated with highly defined epigenetic changes in the human epidermis
Gene group | Gene | Expression (young) | Expression (old) | q value |
|---|---|---|---|---|
Epidermis keratins | KRT1 | 14719.2 | 14954.2 | 1.0 |
KRT2 | 7291.7 | 6154.7 | 1.0 | |
KRT5 | 5860.6 | 5247.7 | 1.0 | |
KRT10 | 26232.1 | 23374.7 | 1.0 | |
KRT14 | 5665.0 | 4430.4 | 1.0 | |
KRT15 | 382.1 | 400.1 | 1.0 | |
Epidermis structural factors | LOR | 613.4 | 427.3 | 1.0 |
FLG | 558.1 | 501.3 | 1.0 | |
FLG2 | 322.5 | 336.5 | 1.0 | |
Fibroblast markers (dermis) | VIM | 41.0 | 54.0 | 1.0 |
DES | <0.1 | <0.1 | 1.0 | |
DNA methylation factors | DNMT1 | 9.5 | 7.3 | 1.0 |
DNMT3A | 1.5 | 1.2 | 1.0 | |
DNMT3B | 1.4 | 1.5 | 1.0 | |
DNMT3L | <0.1 | <0.1 | 1.0 | |
UHRF1 | 1.3 | 1.2 | 1.0 | |
TET1 | 0.1 | 0.1 | 1.0 | |
TET2 | 8.4 | 6.9 | 1.0 | |
TET3 | 18.8 | 14 | 1.0 |