Epigenetics & Chromatin

Table 1 Comparison of EZH2α and EZH2β transcripts yielded by alternative splicing of EZH2 locus transcripts

From: Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression

EZH2α					EZH2β
Exon	Exon size	5^′donor	3^′acceptor	Intron size	Exon	Exon size	5^′donor	3^′acceptor	Intron size
1	186	ACGAAGgtaacgc	cttttagAATAAT	36,858	1	186	ACGAAGgtaacgc	cttttagAATAAT	36,858
2	124	GTAAAGgtataat	ttaaagAGTATG	583	2	124	GTAAAGgtataat	ttaaagAGTATG	583
3	129	AGGGAGgttggtt	gttttagTGTTCG	13,719	3	129	AGGGAGgttggtt	ttttagGTGGAA	16,621
4	117	TTTATGgtatgta	ttttagGTGGAA	2,785	4	121	ATAGAGgtgagcc	gtttcagAATGTG	847
5	121	ATAGAGgtgagcc	gtttcagAATGTG	847	5	141	GAGATGgtatgcc	tgtttagATAAAG	1,473
6	141	GAGATGgtatgcc	tgtttagATAAAG	1,473	6	103	GGAAAAgtaagaa	atgtcagATATAA	531
7	103	GGAAAAgtaagaa	atgtcagATATAA	531	7	164	TACATCgtaagt	tttgcagCTTTTC	6,781
8	179	ATTATTgtacgtt	tttgcagCTTTTC	6,766	8	92	CATTTGgtaagac	ttcgtagGAGGGA	1,478
9	92	CATTTGgtaagac	ttcgtagGAGGGA	1,478	9	241	CCTCTGgtaagac	tttgtagAAGCAA	485
10	241	CCTCTGgtaagac	tttgtagAAGCAA	485	10	170	AGACAGgtaaga	ttgtcagGTGTAT	443
11	170	AGACAGgtaaga	ttgtcagGTGTAT	443	11	95	ACACCGgtgagtc	tttgcagGTTGTG	1,137
12	95	ACACCGgtgagtc	tttgcagGTTGTG	1,137	12	41	AAAAGGgttagca	tactcagACGGCT	466
13	41	AAAAGGgttagca	tactcagACGGCT	466	13	126	CAGAGTgtaagta	tctgaagGTCAAA	776
14	126	CAGAGTgtaagta	tctgaagGTCAAA	776	14	179	AAAAAGgtgagca	tctctagCATCTA	2,238
15	179	AAAAAGgtgagca	tctctagCATCTA	2,238	15	96	GGAGAGgtaaggc	tttttagATTATT	1,210
16	96	GGAGAGgtaaggc	tttttagATTATT	1,210	16	82	ACAATGgtatgtt	cttttagATTTTG	942
17	82	ACAATGgtatgtt	cttttagATTTTG	942	17	81	CAAAAGgtaggta	tttgcagTTATGA	154
18	81	CAAAAGgtaggta	tttgcagTTATGA	154	18	85	TTACAGgttggta	gtttcagATACAG	1,364
19	85	TTACAGgttggta	gtttcagATACAG	1,364	19	335	TTGAATCatctctc	ND
20	335	TTGAATCatctctc	ND

Deposited cDNA sequences for EZH2α (NM_004456.4) and EZH2β (NM_152998.2) were aligned against the most recently published human genome sequence (Feb. 2009 GRCh37/hg19) to determine splice donors, splice acceptors, and exon and intron sizes using the University of California, Santa Cruz BLAT tool. ND: not determined.

Back to article page

ISSN: 1756-8935

Contact us

Submission enquiries: journalsubmissions@springernature.com