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Table 1 Comparison of EZH2α and EZH2β transcripts yielded by alternative splicing of EZH2 locus transcripts

From: Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression

EZH2α EZH2β
Exon Exon
size
5donor 3acceptor Intron
size
Exon Exon
size
5donor 3acceptor Intron
size
1 186 ACGAAGgtaacgc cttttagAATAAT 36,858 1 186 ACGAAGgtaacgc cttttagAATAAT 36,858
2 124 GTAAAGgtataat ttaaagAGTATG 583 2 124 GTAAAGgtataat ttaaagAGTATG 583
3 129 AGGGAGgttggtt gttttagTGTTCG 13,719 3 129 AGGGAGgttggtt ttttagGTGGAA 16,621
4 117 TTTATGgtatgta ttttagGTGGAA 2,785 4 121 ATAGAGgtgagcc gtttcagAATGTG 847
5 121 ATAGAGgtgagcc gtttcagAATGTG 847 5 141 GAGATGgtatgcc tgtttagATAAAG 1,473
6 141 GAGATGgtatgcc tgtttagATAAAG 1,473 6 103 GGAAAAgtaagaa atgtcagATATAA 531
7 103 GGAAAAgtaagaa atgtcagATATAA 531 7 164 TACATCgtaagt tttgcagCTTTTC 6,781
8 179 ATTATTgtacgtt tttgcagCTTTTC 6,766 8 92 CATTTGgtaagac ttcgtagGAGGGA 1,478
9 92 CATTTGgtaagac ttcgtagGAGGGA 1,478 9 241 CCTCTGgtaagac tttgtagAAGCAA 485
10 241 CCTCTGgtaagac tttgtagAAGCAA 485 10 170 AGACAGgtaaga ttgtcagGTGTAT 443
11 170 AGACAGgtaaga ttgtcagGTGTAT 443 11 95 ACACCGgtgagtc tttgcagGTTGTG 1,137
12 95 ACACCGgtgagtc tttgcagGTTGTG 1,137 12 41 AAAAGGgttagca tactcagACGGCT 466
13 41 AAAAGGgttagca tactcagACGGCT 466 13 126 CAGAGTgtaagta tctgaagGTCAAA 776
14 126 CAGAGTgtaagta tctgaagGTCAAA 776 14 179 AAAAAGgtgagca tctctagCATCTA 2,238
15 179 AAAAAGgtgagca tctctagCATCTA 2,238 15 96 GGAGAGgtaaggc tttttagATTATT 1,210
16 96 GGAGAGgtaaggc tttttagATTATT 1,210 16 82 ACAATGgtatgtt cttttagATTTTG 942
17 82 ACAATGgtatgtt cttttagATTTTG 942 17 81 CAAAAGgtaggta tttgcagTTATGA 154
18 81 CAAAAGgtaggta tttgcagTTATGA 154 18 85 TTACAGgttggta gtttcagATACAG 1,364
19 85 TTACAGgttggta gtttcagATACAG 1,364 19 335 TTGAATCatctctc ND  
20 335 TTGAATCatctctc ND       
  1. Deposited cDNA sequences for EZH2α (NM_004456.4) and EZH2β (NM_152998.2) were aligned against the most recently published human genome sequence (Feb. 2009 GRCh37/hg19) to determine splice donors, splice acceptors, and exon and intron sizes using the University of California, Santa Cruz BLAT tool. ND: not determined.