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Table 2 Histone H4 mutants exhibiting altered rapamycin sensitivity

From: Target of rapamycin signaling regulates high mobility group protein association to chromatin, which functions to suppress necrotic cell death

Histone H4 residue Rapamycin phenotype Nucleosome location Source
L10A −1 Tail This study
G14A −1 Tail This study
K20A −1 Disk This study
K20R 0 Disk This study
K20Q −1 Disk This study
L22A −1 Disk This study
G28A −1 Disk This study
I29A −1 Buried This study
S47A −1 Lateral This study
S47D +1 Lateral This study
S64A −1 Disk This study
S64D −1 Disk This study
I66A −1 Buried This study
V81A +1 Buried This study
Y88A −1 Disk This study
Y88E 0 Disk This study
Y88F 0 Disk This study
G94A −1 Disk This study
Y98A −1 Buried This study
Y98E −1 Buried This study
Y98F 0 Buried This study
Total number of H4 mutants screened 94
Number of H4 mutants with phenotype 13
Percentage of total H4 mutants with phenotype 13.8%
Percentage of H4 mutants with resistant phenotypes 7.7%
Percentage of H4 mutants with sensitive phenotypes 92.3%