Table 2 Histone H4 mutants exhibiting altered rapamycin sensitivity
Histone H4 residue | Rapamycin phenotype | Nucleosome location | Source |
|---|---|---|---|
L10A | −1 | Tail | This study |
G14A | −1 | Tail | This study |
K20A | −1 | Disk | This study |
K20R | 0 | Disk | This study |
K20Q | −1 | Disk | This study |
L22A | −1 | Disk | This study |
G28A | −1 | Disk | This study |
I29A | −1 | Buried | This study |
S47A | −1 | Lateral | This study |
S47D | +1 | Lateral | This study |
S64A | −1 | Disk | This study |
S64D | −1 | Disk | This study |
I66A | −1 | Buried | This study |
V81A | +1 | Buried | This study |
Y88A | −1 | Disk | This study |
Y88E | 0 | Disk | This study |
Y88F | 0 | Disk | This study |
G94A | −1 | Disk | This study |
Y98A | −1 | Buried | This study |
Y98E | −1 | Buried | This study |
Y98F | 0 | Buried | This study |
Total number of H4 mutants screened | 94 | ||
Number of H4 mutants with phenotype | 13 | ||
Percentage of total H4 mutants with phenotype | 13.8% | ||
Percentage of H4 mutants with resistant phenotypes | 7.7% | ||
Percentage of H4 mutants with sensitive phenotypes | 92.3% | ||