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Table 1 Histone H3 mutants exhibiting altered rapamycin sensitivity

From: Target of rapamycin signaling regulates high mobility group protein association to chromatin, which functions to suppress necrotic cell death

Histone H3 residue Rapamycin phenotype Nucleosome location Source
A1S −1 Tail This study
T3A +1 Tail This study
T3D 0 Tail This study
Q5A +2 Tail This study
Q5E +2 Tail This study
K14A −2 Tail [36]
K14R 0 Tail This study
K14Q 0 Tail This study
R17A −2 Tail This study
R17K −2 Tail This study
K18A −1 Tail [36]
K18R −2 Tail This study
K18Q 0 Tail This study
K23A −1 Tail [36]
K23R 0 Tail This study
K23Q 0 Tail This study
S28A −2 Tail This study
S28D 0 Tail This study
P30A −1 Tail This study
K37A Lethal Tail This study
K37R 0 Tail This study
K37Q 0 Tail This study
R49A −2 Lateral This study
R49K 0 Lateral This study
K56A −3 Lateral [36]
K56R −2 Lateral [36]
K56Q +2 Lateral [36]
S57A +1 Disk [36]
S57D +1 Disk [36]
E73A −1 Disk This study
E73Q −1 Disk This study
Q76A −1 Disk This study
Q76E −1 Disk This study
T80A +1 Disk This study
T80D −1 Disk This study
L82A −1 Disk This study
R83A −2 Lateral This study
R83K 0 Lateral This study
Q85A −2 Lateral This study
Q85E 0 Lateral This study
S86A −2 Lateral This study
S86D −2 Lateral This study
L92A +1 Buried This study
E105A −1 Disk This study
A110S −1 Buried This study
A111S −1 Buried This study
A114S −1 Disk This study
V117A −3 Lateral This study
Q120A +1 Lateral This study
K121A −1 Disk This study
K121R 0 Disk This study
K121Q −1 Disk This study
K122A −1 Disk This study
K122R −3 Disk This study
K122Q −1 Disk This study
R129A +1 Disk This study
R129K 0 Disk This study
Total number of H3 mutants screened 114
Number of H3 mutants with phenotype 30
Percentage of total H3 mutants with phenotype 26.3%
Percentage of H3 mutants with resistant phenotypes 26.7%
Percentage of H3 mutants with sensitive phenotypes 73.3%