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Table 2 Referenced pathways enriched in the epithelial-mesenchymal transition-related gene clusters (EMT-GCs)

From: Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition

GC Pathway name Enrichment p-value
16 Pathways in cancer 4.618 0.00000627
16 Direct p53 effectors 8.279 0.00000023
16 p53 signaling pathway 7.100 0.09600000
16 Focal adhesion 5.298 0.00013609
16 ECM-receptor interaction 6.963 0.01242671
16 Cytokines and inflammatory response 18.189 0.00875280
16 Interleukin-1 processing 54.274 0.01740033
16 T cell receptor signaling pathway 8.320 0.00000663
16 TNF-alpha/NF-kB signaling pathway 4.280 0.03567735
16 CD40/CD40L signaling 13.097 0.04278382
16 MAPK signaling pathway 3.493 0.09603616
19 Pathways in cancer 5.303 0.00000226
19 Focal adhesion 6.245 0.00003282
19 E-cad sig in the nasc adherens junction 24.776 0.00000267
19 Regulation of actin cytoskeleton 6.012 0.00571942
19 Adherens junction 13.011 0.00000273
19 Junction 14.070 0.00496435
19 Canonical NF-kappaB pathway 20.435 0.00422071
19 MAPK signaling pathway 4.918 0.08357500
19 Leukocyte transendothelial migration 8.442 0.00006173
19 T cell receptor signaling pathway 8.321 0.00000663
19 TGF-beta receptor signaling 15.678 0.00001359
  1. Pathways significantly enriched in GC16 and GC19. Only pathways directly referenced in the manuscript are shown. Pathways have been sourced from the NCBI Biosystems. Enrichment is the fold-change relative to the background frequency of a pathway annotation. P values are calculated by Fisher’s Exact Test and are false discovery rate (FDR) corrected.