Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition

Table 2 Referenced pathways enriched in the epithelial-mesenchymal transition-related gene clusters (EMT-GCs)

GC	Pathway name	Enrichment	p-value
16	Pathways in cancer	4.618	0.00000627
16	Direct p53 effectors	8.279	0.00000023
16	p53 signaling pathway	7.100	0.09600000
16	Focal adhesion	5.298	0.00013609
16	ECM-receptor interaction	6.963	0.01242671
16	Cytokines and inflammatory response	18.189	0.00875280
16	Interleukin-1 processing	54.274	0.01740033
16	T cell receptor signaling pathway	8.320	0.00000663
16	TNF-alpha/NF-kB signaling pathway	4.280	0.03567735
16	CD40/CD40L signaling	13.097	0.04278382
16	MAPK signaling pathway	3.493	0.09603616
19	Pathways in cancer	5.303	0.00000226
19	Focal adhesion	6.245	0.00003282
19	E-cad sig in the nasc adherens junction	24.776	0.00000267
19	Regulation of actin cytoskeleton	6.012	0.00571942
19	Adherens junction	13.011	0.00000273
19	Junction	14.070	0.00496435
19	Canonical NF-kappaB pathway	20.435	0.00422071
19	MAPK signaling pathway	4.918	0.08357500
19	Leukocyte transendothelial migration	8.442	0.00006173
19	T cell receptor signaling pathway	8.321	0.00000663
19	TGF-beta receptor signaling	15.678	0.00001359

Pathways significantly enriched in GC16 and GC19. Only pathways directly referenced in the manuscript are shown. Pathways have been sourced from the NCBI Biosystems. Enrichment is the fold-change relative to the background frequency of a pathway annotation. P values are calculated by Fisher’s Exact Test and are false discovery rate (FDR) corrected.

ISSN: 1756-8935