Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition

Table 1 Referenced GO-terms enriched in the epithelial-mesenchymal transition-related gene clusters (EMT-GCs)

Gene cluster	GO-term	Enrichment	P value
16	Wound healing	13.568	0.00001057
16	Plasma membrane	1.982	0.00018160
16	Receptor binding	4.840	0.00024000
16	Seq-spec DNA binding TF activity	2.580	0.00600000
16	Signal transduction	2.523	<1e-8
16	Cellular process	2.651	<1e-8
16	Cell communication	2.358	<1e-8
16	Cell motility	4.231	<1e-8
16	Basement membrane	8.739	0.00959450
16	Cell differentiation	3.078	<1e-8
16	Aging	6.851	0.00000083
16	Growth	3.286	0.00008581
16	Cell death	3.859	<1e-8
16	Cell proliferation	3.901	<1e-8
16	Negative regulation of apoptosis	6.253	0.00000023
16	Immune system process	2.988	<1e-8
16	Cytokine production	4.981	0.00000346
16	Developmental process	3.105	<1e-8
16	MAP kinase tyr/ser/thr phosphat activity	34.020	0.02600000
16	Inactivation of MAPK activity	20.460	0.02400000
16	Pos reg of NF-kappaB TF activity	9.340	0.00150000
19	Plasma membrane	2.022	0.00142517
19	Signal transduction	2.790	<1e-8
19	Cellular process	2.108	0.00001248
19	Cell communication	2.671	<1e-8
19	Cell motility	3.425	0.00023150
19	Focal adhesion	8.441	0.00341880
19	Cell differentiation	2.532	0.00000486
19	Cell death	2.519	0.00059504
19	Cell proliferation	2.765	0.00016907
19	Immune system process	2.302	0.02549018
15	Cellular process	2.010	0.00000250
15	Sequence-specific DNA binding	2.990	0.02700000
15	Developmental process	1.930	0.00042000
15	Cell differentiation	1.910	0.05200000
15	Cell death	2.220	0.00380000
15	Anatomical structure development	1.980	0.00098000
15	Cell proliferation	1.980	0.00690000

GO-terms significantly enriched in GC15, GC16, and GC19. Only GO-terms directly referenced in the manuscript are shown. GO-term annotations are obtained from GOA and NCBI. Enrichment is the fold-change relative to the background frequency of a GO-term annotation. P values are calculated by Fisher’s Exact Test and are false discovery rate (FDR) corrected.

ISSN: 1756-8935