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Table 1 Referenced GO-terms enriched in the epithelial-mesenchymal transition-related gene clusters (EMT-GCs)

From: Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition

Gene cluster GO-term Enrichment P value
16 Wound healing 13.568 0.00001057
16 Plasma membrane 1.982 0.00018160
16 Receptor binding 4.840 0.00024000
16 Seq-spec DNA binding TF activity 2.580 0.00600000
16 Signal transduction 2.523 <1e-8
16 Cellular process 2.651 <1e-8
16 Cell communication 2.358 <1e-8
16 Cell motility 4.231 <1e-8
16 Basement membrane 8.739 0.00959450
16 Cell differentiation 3.078 <1e-8
16 Aging 6.851 0.00000083
16 Growth 3.286 0.00008581
16 Cell death 3.859 <1e-8
16 Cell proliferation 3.901 <1e-8
16 Negative regulation of apoptosis 6.253 0.00000023
16 Immune system process 2.988 <1e-8
16 Cytokine production 4.981 0.00000346
16 Developmental process 3.105 <1e-8
16 MAP kinase tyr/ser/thr phosphat activity 34.020 0.02600000
16 Inactivation of MAPK activity 20.460 0.02400000
16 Pos reg of NF-kappaB TF activity 9.340 0.00150000
19 Plasma membrane 2.022 0.00142517
19 Signal transduction 2.790 <1e-8
19 Cellular process 2.108 0.00001248
19 Cell communication 2.671 <1e-8
19 Cell motility 3.425 0.00023150
19 Focal adhesion 8.441 0.00341880
19 Cell differentiation 2.532 0.00000486
19 Cell death 2.519 0.00059504
19 Cell proliferation 2.765 0.00016907
19 Immune system process 2.302 0.02549018
15 Cellular process 2.010 0.00000250
15 Sequence-specific DNA binding 2.990 0.02700000
15 Developmental process 1.930 0.00042000
15 Cell differentiation 1.910 0.05200000
15 Cell death 2.220 0.00380000
15 Anatomical structure development 1.980 0.00098000
15 Cell proliferation 1.980 0.00690000
  1. GO-terms significantly enriched in GC15, GC16, and GC19. Only GO-terms directly referenced in the manuscript are shown. GO-term annotations are obtained from GOA and NCBI. Enrichment is the fold-change relative to the background frequency of a GO-term annotation. P values are calculated by Fisher’s Exact Test and are false discovery rate (FDR) corrected.