Epigenetic clustering groups functionally similar genes and identifies epithelial-mesenchymal transition (EMT)-related clusters. (A) Assessment of EMT functions in gene clusters. Degree of functional similarity between the epigenetic gene clusters and two lists of genes associated with EMT corresponding to genes obtained by manual literature mining and those annotated with GO-terms that included EMT. Functional Similarity Scores (FSS) of each cluster to the two reference EMT gene lists are plotted. (B) Functional similarity of gene clusters. Heat map shows the hierarchical clustering of the Functional Correlation Matrix of epigenetic gene clusters. A trimmed dendrogram of the clustering is shown. Each row represents a ‘source’ gene cluster while each column represents either the enrichment (E) or depletion (D) score with a ‘target’ cluster. The sum of the E and D scores is the FSS for a given cluster pair. Columns are arranged numerically by cluster ID.