Enrichment of GO terms with nearest genes of tDMRs. Different colours represent the distinct major classes. Notice the difference in major classes between genes enriched with tDMRs that have a CGI or CGI flanking region and those which do not. When no CGI is present, tissue-specific genes are observed, while when there is a CGI present, the genes enriched with a tDMR are more often involved in embryonic developmental processes and gene regulation genes. Genes with a differentially methylated shelf overlapping with the proximal promoter, were associated with developmental -, housekeeping -, and tissue-specific GO terms. CGI, CpG island; GO, gene ontology; tDMR, tissue-specific differentially methylated region.