Global domain post-translational modifications. (a) The nucleosome with H3 (blue), H4 (green), H2A (red) and H2B (yellow). (b) Tryosine hydroxylation on H2BY83 (cyan) and H4Y88 (purple) occur at the H2B:H4 interface. (c) Glutathionylation of H3C110 mapped to the H3:H4 tetramer interface. (d) Phosphorylation on H3T45 (pink) and H3Y41 (yellow) mapped to the H3:H4 tetramer. (e) Phosphorylations from (d) occur near the H3:DNA contact.