Figure 5
From: Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4
Crosstalk between adenosine diphosphate-ribosyltransferase (ARTD)-1 and SET7/9-dependent modification of linker and core histones. (A) Summary of known post-translational modification sites of H1.4. The grey box marks the central globular domain. The six newly identified KAK motifs that are methylated by SET7/9 are highlighted in red. Blue: PARylation (PAR), red: phosphorylation (P), green: methylation (me, number indicates methylation state). (B) Model of the sequential adenosine diphosphate (ADP)-ribosylation and methylation reactions on histone H3 and H1 by ARTD1 and SET7/9.