Figure 5
From: Genome-wide DNA methylation profiling of non-small cell lung carcinomas
Methylation-specific polymerase chain reaction screening in 48 tumors and matching lung tissues. (A) Cropped gel images for the seven patients used for MethylCap-seq, grouped by histological subtype and controls (M: “methylated primer set”; N: lung; T: tumor; Tot_M: totally methylated control samples; Tot_U: totally unmethylated control sample; U: unmethylated primer set; ø: blank/water). (B) Histogram of the methylation status in lung samples and tumor samples in all 48 patients in the five fragments analyzed. (C) Histogram of the methylation status per histological subtype (statistics were calculated with Fisher’s exact test, two-tailed p-values: *P≤0.02; **P≤0.001 and ***P≤0.01).