Correlation of Benzonase accessible regions with epigenetic marks. Tags from all three Benzonase concentrations were combined and identified hotspots were divided into quartiles according to the hotspots tag density, where the top 25% represents the most intense hotspots and the low 25% represents the least intense hotspots. (A) Distribution of hotspots in promoters (2 kb upstream TSS), distal/intergenic regions, introns, exons and downstream regions (2 kb downstream TTS). Tag density of H3K4me3 (B), H3K4me1 (D), H3K27me3 (E) 3.5 kb up and downstream from Benzonase hotspots. (C) Liver MNase-seq tag density surrounding the Benzonase hotspots.