Figure 2
From: Extensive epigenetic reprogramming in human somatic tissues between fetus and adult
Heat-map of 98 loci showing hypermethylated or hypomethylated tissue-specific differentially methylated regions (tDMRs) in particular tissues. Probes and sample names are shown and with hierarchical clustering of Ī² values based on the formula 1-r (Beadstudio software; Illumina), where r is the correlation coefficient between samples. A Ī² value of 0 (bright green) represents an unmethylated locus, and a value of 1 (bright red) represents a methylated locus. Hypermethylated and hypomethylated loci were defined as those having an average Ī² value in that tissue of >0.2 above or below the overall mean for all tissues. Fetal brain had the highest number of tDMRs, with 30 hypermethylated and 23 hypomethylated loci.