Skip to main content
Figure 5 | Epigenetics & Chromatin

Figure 5

From: Role of the ATPase/helicase maleless (MLE) in the assembly, targeting, spreading and function of the male-specific lethal (MSL) complex of Drosophila

Figure 5

Summary of the known interactions of the male-specific lethal (MSL) complex subunits. MSL1 and MSL2 form a DNA-binding module, the specificity of which requires the association of MSL2 with roX RNA. The association of MSL1 and MSL3 with MOF enhances its histone acetyltransferase activity and specificity. MLE and MSL2 interact and contribute to MOF activity. Maleless (MLE) is responsible for the incorporation of roX RNA in the complex and requires roX RNA to associate with the complex. The roX RNA is needed for full histone acetylation. Please see the discussion section for details of these associations.

Back to article page

Epigenetics & Chromatin

ISSN: 1756-8935